Nutritional supplement

Composition

One capsule contains: 

• Saw Palmetto (Serenoa serrulata) extract                   -  260 mg,
• Saw Palmetto (Serenoa serrulata) berries powder          -    5 mg,
• African prune (Pygeum africanum) extract  powder        -   25 mg,
• Pumpkin (Cucurbita pepo) seed powder                       -   10 mg,
• Vitamin E                                                                 -   10 mg,
• Zinc                                                                       -  0,86 mg.

Recommendations for use:

• prostate function disorders, urination disorders,
• suitable to use in case of androgenic alopecia.

Action of active substances

Saw palmetto extract

Originally saw palmetto comes from USA. Native American Indians used saw palmetto fruits because of their specific taste as spice and as medicine. Saw palmetto fruit tea was recommended for men with urination disorder. It was believed in the beginning of the 20th century that the fruits of this plant improve sperm production and sexuality. Clinical research in the last decades showed that saw palmetto extract can be useful for men to keep good prostate tissue structure and function. It was determined that saw palmetto extract has a positive effect on the prostate gland structure and function because it inhibits 5-alfa reductase, testosterone transformation into dihydrotestosterone and does not allow dihydrotestosterone to join the cell receptors. Saw palmetto extract protects from inflammation because it reduces the synthesis of the inflammatory prostaglandins and leukotrienes. Phytosterols that are in the extract reduce the symptoms of the benign prostate hyperplasia, stop alopecia, and stimulates the growth of the hair. It is also determined that phytosterols effectively improve urination function, urination stream, decrease the residual urine amount, diminishes the swelling of the prostate tissue and inhibit the proliferation of the prostate epithelial cells.

Prunus (Pygeum africanum)

Prunus (Pygeum africanum)  extract improves prostate function, reduces residual urine amount, increases urine stream and synthesis of the inflammatory prostaglandins.

Pumpkin seeds

Pumpkin seeds contain phytosterols, vitamin E, manganese, and selenium. These substances have a positive effect in the metabolism and function of the muscle tissue of the bladder, decrease the rate of urination disorders.

Vitamin E

Vitamin E is an antioxidant that protects prostate from free radicals.

Zinc

Zinc has an anti-inflammatory effect.

Scientific researches demonstrating the efficiency

* USA Urology Association announced randomised placebo controlled study results in the conference in 2001: prostate tissue biopsy results showed that dihydrotestosterone (the cause of the enlargement of the prostate) decreased 32 percent after administration of saw palmetto for six months. Saw palmetto effectively reduced the symptoms of benign prostate hyperplasia.
* USA Medical Association journal reviewed the results of 18 clinical studies. They showed that saw palmetto extract was safe and effectively reduceed prostate hyperplasia symptoms. (Effects of saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. Marks et al. Journal of Urology. 2000 May 163(5): 1451-6)
* More than 20 randomized placebo controlled studies on the saw palmetto effect to prostate were performed in 2001. A conclusion was made according to international prostate symptom scale that saw palmetto much more effectively than placebo decreased the symptoms of benign prostate hyperplasia, improved the subjective state of the patients and decreased urination during the night rate. 2 comparative studies with chemical medicines for prostate hyperplasia treatment were also performed. The effects of saw palmetto extract and chemical medicines were similar and saw palmetto did not caused side effects like chemical medicines. (Gerber GS, Kuznetsov D, Johnson BC, Burstein JD. Randomized, double-blind, placebo-controlled trial of saw palmetto in men with lower urinary tract symptoms. Urology 2001;58:960-4.)

Literature:

1. Carraro JC, Raynaud JP, Koch G, Chisholm GD, Di Silverio F, Teillac P, et al. Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996;29: 231¬40.
2. Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998;280.
3. Braeckman J, Denis L, de Leval J, et al. A double blind, placebo controlled study for the plant extract Serenoa repens in the treatment of benign prostate. Eur J Clin Res 1997;9:247-59.
4. Blumethal M, editor. The complete German Commission E monographs. Austin (TX): American Botanical Council; 1998.
5. Lowe FC, Ku JC. Phytotherapy in the treatment of benign prostatic hyperplasia: a critical review. Urology 1996;48:12-20.
6. Morganti P, Fabrizi G, James B, Bruno C. Effect of gelatine-cystine and Serenoa repens extract on free radical levels and hair growth. J Appl Cosmetol 1998;16:57-64
7. Lowe FC, Ku JC. Phytotherapy in treatment of benign prostatic hyperplasia: a critical review. Urology 1996;48:12-20.
8. Briley M, Carilla E, Roger A. Inhibitory effect of Permixon on testosterone 5a-reductase activity of the rat ventral prostate. Br J Pharmacol 1984;83 (suppl):401P.
9. Marks LS, Hess DL, Dorey FJ, Macairan ML, Cruz Santos PB, Tyler VE. Tissue effects of saw palmetto and finasteride: use of biopsy cores for in situ quantification of prostatic androgens. Urology 2001;57:999-1005.
10. Marks, LS, Partin AW, Epstein JI, Tyler VE, Simon I, Macairan ML, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6.
11. Wilt T, Ishani A, MacDonald R. Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev 2002;3:CD001423.
12. Gerber GS, Kuznetsov D, Johnson BC, Burstein JD. Randomized, double-blind, placebo-controlled trial of saw palmetto in men with lower urinary tract symptoms. Urology 2001;58:960-4.