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Nutritional supplement 
Composition One capsule contains: - Magnesium - 200 mg,
- Vitamin B1 - 15 mg,
- Vitamin B2 - 15 mg,
- Vitamin B6 - 15 mg,
- Vitamin B12 - 25 mcg,
- Nicotinamide - 50 mg,
- Biotin - 200 mcg,
- Calcium pantothenate 25 mg.
Recommendations for use: - in case of increased sensitivity and irritability,
- while feeling permanent weariness and stress,
- while feeling headache,
- in case of disturbed heartbeat,
- while having convulsions,
- in case of increased blood pressure,
- in order to replenish the missing amount of magnesium and B-group vitamins.
Influence of active materials Magnesium In various compounds of magnesium there is an unequal amount of elemental magnesium. The largest amount of pure magnesium is found in magnesium oxide. In magnesium oxide there are 5,9-12 times more of elemental (pure) magnesium than in organic magnesium salts (lactate, gluconate, aspartate). Magnesium oxide reduces enlarged gastric acidity, melts properly in gastric juices and composes a form of magnesium that is easy to adopt – magnesium chloride, which is very easily adopted in the thin intestine and does not interfere with intestine microflora.
Magnesium is one of the most important minerals. In the organism of the adult two thirds of magnesium are found in bones. Magnesium participates in the activity of nervous system, in the processes of thermoregulation, regulates systoles‘ rate and force, relaxes muscles, necessary for concentration of energy in the cells, important for calcium circulation. Magnesium also widens vessels, regulates blood pressure, improves peripheral blood circulation. In case the amount of magnesium in the blood is too small, the amount of calcium and kalium also is being reduced.
The lack of magnesium may develop because of the usage of alcohol and coffee, in case of burns, hypercalcemia, diabetes, diarrhoea, being on a diet, taking exercises, often experiencing stress, sweating strongly. B-group vitamins B-group vitamins dissolve in water. The organism assimilates them properly while using per os. B1 – participates in the circulation of carbohydrates, also while transferring nerve impulse to muscles, stimulates normal development, reduces phenomena of acidosis. B2 – influences fat assimilation, important for sight, stimulates formation of erythrocytes and antibodies, helps to keep the skin, mucous membranes and hair healthy, stimulates functions of adrenals. B6 – influences enzymatic processes that proceed in the organism and particularly in encephalon, promotes production of haemoglobin and circulation of fat and carbohydrates. B12 – participates in important processes of metabolism, regulates concentration of energy in muscular tissue and also processes of blood formation. Participates in the processes of cell division, when genetic information is being transferred to new cells. Nicotinamide – participates in oxidation – reduction reactions, important for hormone synthesis and secretion of bile and gastric juices. Biotin – participates in the processes of metabolism, synthesis of fat acids, gluconeogenesis. Calcium pantothenate - participates in the metabolism of proteins, fat and carbohydrates as coferment, functions liportopically, detoxificationly.
Initial phenomena of vitamin deficiency: general weakness, rapid weariness, lack of appetite, decreased immunity of the organism. Special deficiencies of separate vitamins emerge later.
Deficiency phenomena of vitamin B1: inflammatory diseases of peripheral nerve, cardiomyopathies, disorders of action of the heart, disorders of digestive tract, insufficiency phenomena of thyroid and hypophysis functions.
Deficiency phenomena of vitamin B2: cheilosis is characteristic; it manifest mucous membrane (especially in the mouth) violation. Emerge eyestrain, fear of light, painful tears in the corners of lips, glossitis, skin inflammation.
Deficiency phenomena of vitamin B6: emerges seborrheal dermatitis, anaemia, liver fatty infiltration, epileptiformal convulsions, ataxy.
Deficiency phenomena of vitamin B12: anaemia, smart pains in mouth cavity, atrophy of tongue nipples, taste of the food is understood worse, the tongue becomes flat, red, emerges nausea.
Deficiency phenomena of nicotinamide: memory and contemplation are violated, develops pellagra, the look of the skin changes, the activity of nervous system and digestive organs is being changed, evolve throes of peripheral vessels.
Deficiency phenomena of biotin: muscle pain, desquamation of legs and arms skin, depression.
Deficiency phenomena of calcium pantothenate: hair slip and chip, inflammatory violations of the skin.
B-group vitamins are necessary for the safeguard of normal metabolic processes. Combination of B-group vitamins, which is being used in larger amounts than usually, distinguishes for efficient analgesic effect and helps to suppress various inflammatory pains.
Dosage To take 1 capsule 1-2 times per day during the meal or after it. Literature: 1.Cox IM, Campbell MJ, Dowson D. Red blood cell magnesium and chronic fatigue syndrome. Lancet 1991;337:757–60.
2. Howard JM, Davies S, Hunnisett A. Magnesium and chronic fatigue syndrome. Lancet 1992;340:426.
3. NM. Magnesium and chronic fatigue. Lancet 1991;338:66 [letter].
4. Hinds G, Bell NP, McMaster D, McCluskey DR. Normal red cell magnesium concentrations and magnesium loading tests in patients with chronic fatigue syndrome. Ann Clin Biochem 1994;31(Pt 5):459–61.
5. Heap LC, Peters TJ, Wessely S. Vitamin B status in patients with chronic fatigue syndrome. J R Soc Med 1999;92:183–5.
6. Grant JE, Veldee MS, Buchwald D. Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome. J Am Diet Assoc 1996;96:383–6.
7. Snow CF. Laboratory diagnosis of vitamin B12 and folate deficiency. A guide for the primary care physician. Arch Intern Med 1999;159:1289–98 [review].
8. Rana S, D’Amico F, Merenstein JH. Relationship of vitamin B12 deficiency with incontinence in older people. J Am Geriatr Soc 1998;46:931 [letter].
9. Pharmacology 1986 m., 316–320 pages.
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