Nutritional supplement

Composition

One capsule contains:

• Glucosamine sulphate sodium chloride  1000 mg.

Recommendations for use:

• articular diseases.

Action of active substances

Glucosamine

Glucosamine is amine polysaccharide and can be found in every tissue of human body, mostly in cartilages. More than 24 years glucosamine sulphate is used for the treatment of osteoarthritis in Europe. Glucosamine is a substance that keeps the cartilages elastic, strong and solid. Organism produce glucosamin in small amounts, but with years the production of glucosamine becomes more slow. Glucosamine sulphate not only reduce the articular pain and inflammation but also reduce the cause of the disease, renews the structure of articular cartilages, retards the progress of the disease, increase the synthesis of inflammation reducing substances. Glucosamine not only protects cartilages from fragmentation but stimulates the regeneration. Clinical trials proved that glucosamine has a positive effect and cause no side effects.

Scientific researches demonstrating the efficiency

* The randomized, placebo controlled trials that were carried out for three years with 212 patients with knee osteoarthritis were recorded. The effect of glucosamine and placebo was compared. The administration of glucosamine markedly relieved the articular pain, stopped the process and progress of cartilage fragmentation. Placebo group didn't show any of these changes. .( McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteo-arthritis: a systematic quality assessment and meta-analysis. JAMA 2000; 283:1469-1475).
* Double blind, placebo controlled, randomized trials were performed. The effect of glucosamine was compared with the effect of ibuprofen. Ibuprofen had more instant outset of action but after 4 weeks the effect of two drugs was the same. But ibuprofen caused some undesirable reactions (especially in digestion organs). (Müller-Fassbender H, Bach GL, Haase W, Rovati LC, Setnikar I. Glucosamine sulfate in osteoarthritis of the knee. Osteoarthritis Cartilage 1994; 2:61-69).
* Long lasting more than 3 years performed trial proved the eficacy and safety of glucosamine. Glucosamine is widely used for the treatment of articular diseases, especially when patients cannot use nonsteroidal antiinflammatory drugs because of gastrointestinal tract disturbances (stomach mucous inflammation, erosions). Glicosamine sulphate does not irritate stomach and does not cause ulcerous disease.
* Randomized, double blinded trial was performed with 146 patients with osteoarthritis. The effect of chondroitin and diclophenac was compared. The effect of diclophenac is more sudden but short lasting. The effect of chondroitin appears later but is long lasting. (Pamela Mason. Dietary supplements, second edition, 54 psl.)
* 1500 patients with osteoarthritis received glucosamine, chondroitin, combination of both substances, celecocib and placebo. Trial lasted 24 weeks. The effect of glucosamine - chondroitin or celecocib was much better than placebo. There were no undesirable side effects of glucosamine - chondroitin. (Glucosamine/chondroitin Arthritis Intervention Trial, 2005)

Dosage

1 capsule 1 to 2 times daly.

Literature:

1. McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteo-arthritis: a systematic quality assessment and meta-analysis. JAMA 2000; 283:1469-1475. 2. Müller-Fassbender H, Bach GL, Haase W, Rovati LC, Setnikar I. Glucosamine sulfate in osteoarthritis of the knee. Osteoarthritis Cartilage 1994; 2:61-69.
3. P. Mason Dietary supplements Gliucosamine 2001 p.118–121.
4. L.C. Rovati, G.Giacovelli, ir kt. A large, randomized, placebo-controlled, double-blind study of glucosamine sulfate vs piroxicam vs and their association on the kinetics of the symptomatic effect in knee osteoarthritis (abstract). Ostheoarth. Cart. 1994; 2 (suppl. 1):56.
5. T. McAlindon, ir kt. Gliucosamine for osteoarthritis: dawn of a new era? Lancet 2001 357, 247–8 (Commentary).
6. N.M.R. Thie ir kt. Evaluation of glucosasamine sulfate compared to ibuprofen for treatment of temporomandibular joint osteoarthritis: arandomized double blind controled 3 month trial. J Rheumatol 2001 28, 1347-55.
7. Bland, J.H., Cooper, S.M. Osteoarthritis: A review of the cell biology involved and evidence for reversibility. Management rationally related to known genesis and pathophysiology. Seminars in Arthritis and Rheumatism 1984;14(2):106-133.