HOME
Calcium + D3 Print E-mail

 Nutritional supplement

Image

Composition

One tablet contains:

  • Calcium         - 400 mg,
  • Vitamin D       -  5 mcg.
Recommendations for use:
  • increased Calcium and Vitamin D3 requirements in young and growing people,
  • prevention of osteoporosis in elder people,
  • poor Calcium and Vitamin D3 assimilation.


Effect of active substances

Vitamin D3

Vitamin D (calcipherol) is a fat soluble vitamin. The most important forms of it include Vitamin D2 (ergocalcipherol) and Vitamin D3 (cholecalcipherol). The sources of Vitamin D are fish oil, fatty fish, and yolk. One of the main functions of Vitamin D3 includes regulation of calcium, magnesium and phosphorus circulation. Vitamin D3 helps to retain these substances in bones, combats atherosclerosis, and regulates assimilation of calcium and phosphorus in intestines. Major amounts of Vitamin D are necessary in pregnancy or in cases of kidney and liver disorders. Vitamin D deficiency results in softening of bones, disorders of teeth growth.

Calcium

Calcium is one of the most important minerals for human body. It is important for strong bones. The largest quantities of calcium are in bones and teeth and it is responsible for strong bones and teeth. Small quantities of calcium circulating in blood help in forming substances responsible for regulation of digestion, energy circulation and metabolism. Calcium expedites entrance of nutrients into the cell and is also important for maintenance of cell membrane permeability and spread of nervous impulse to muscles as well as for blood coagulation. Over 90 percent of calcium present in human body is located in bones in the form of carbonates and phosphates. All the above functions remove calcium from bones. Therefore in cases of calcium deficiency human bones become fragile, weak and result in osteoporosis or possible bone fractures. Calcium resorption from intestines and mobilization from bones is assisted by Vitamin D.

Effect of active substances

* People over 65 treated by calcium and Vitamin D for three years reported slower decrease in bone mass and reduced cases of fractures by 7 percent (Dawson-Hughes)
* Multicentral researches evidence that calcium intake by pregnant women may prevent pregnancy- related arterial blood pressure. (Levine RJ, Hauth JC, Curet LB, et al. Trial of calcium to prevent preeclampsia. N Engl J Med. 1997;337(2):69-76.)
* Placebo controlled researches show that calcium intake by elder women helps to reduce weight. (Davies KM, Heaney RP, Recker RR, Lappe JM, Barger-Lux MJ, Rafferty K, Hinders S. Calcium intake and body weight. J Clin Endocrinol Metabol. 2000;85(12):4635-4638.)
* Calcium may help to prevent blood pressure and is recommended as an additional measure in hypertension treatment. (Miller GD, DiRienzo DD, Reusser ME, McCarron DA. Benefits of dairy product consumption on blood pressure in humans: a summary of the biomedical literature. J Am Coll Nutr. 2000;19(2 Suppl):147S-164S)

Dosage

1 tablet once or twice per day.

Literature:

1. Horrobin K. Calcium metabolism, osteoporosis and essential fatty acids: a review. Progress in Lipid Research, 1997;36(2- 3):131-151.
2. Papendorp D, Coetzer H, Kruger M. Biochemical profile of osteoporotic patients on essential fatty acid supplementation. Nutrition Research, 1995;15(3):325-334.
3. Siggurdson G, Franzson L. The association between parathyroid hormone, vitamin D and bone mineral density in 70 – years - old Icelandic women. Osteoporosis. Int.2000;11;1031-5.
4. Watkins BA, Lippman HE. Bioactive fatty acids: role in bone biology and bone cell function. Prog.Lipid Res. 2001;40:125-48.
5. Calvo MS. Dietary considerations to prevent loss of bone and renal function. Nutrition. 2000;16(7-8):564-566. (PubMed)
6. Devine A, Criddle RA, Dick IM, Kerr DA, Prince RL. A longitudinal study of the effect of sodium and calcium intakes on regional bone density in postmenopausal women. Am J Clin Nutr. 1995;62(4):740-745. (PubMed)
7. Weaver CM, Proulx WR, Heaney R. Choices for achieving adequate dietary calcium with a vegetarian diet. Am J Clin Nutr. 1999;70(3 Suppl):543S-548S. (PubMed)
8. 12. Bostick R. Diet and nutrition in the prevention of colon cancer. In: Bendich A, Deckelbaum RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals. 2nd ed. Totowa: Humana Press, Inc; 2001:57-95.
9. Baron JA, Beach M, Mandel JS, et al. Calcium supplements and colorectal adenomas. Polyp Prevention Study Group. Ann N Y Acad Sci. 1999;889:138-145. (PubMed)
10. Bonithon-Kopp C, Kronborg O, Giacosa A, Rath U, Faivre J. Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European Cancer Prevention Organisation Study Group. Lancet. 2000;356(9238):1300-1306. (PubMed)
11. Specker BL. Evidence for an interaction between calcium intake and physical activity on changes in bone mineral density. J Bone Miner Res. 1996;11(10):1539-1544. (PubMed)
12. Martini LA, Wood RJ. Should dietary calcium and protein be restricted in patients with nephrolithiasis? Nutr Rev. 2000;58(4):111-117. (PubMed)
13. Heller HJ. The role of calcium in the prevention of kidney stones. J Am Coll Nutr. 1999;18(5 Suppl):373S-378S. (PubMed)
14. Curhan GC, Willett WC, Rimm EB, Stampfer MJ. A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med. 1993;328(12):833-838. (PubMed)

 
Next >