Nutritional supplement

Composition

One tablet contains:

• Glucosamine sulfate           -  500 mg,
• Chondroitine sulfate          -  400 mg,
• Metilsulfonilmetane (MSM)  -  375 mg.

Recommendations for use:

• improvement in joint function.

Action of active substances

Glucosamine sulphate

Glucosamine is amine polysaccharide and can be found in every tissue of human body, mostly in cartilages. With years production of glucosamine decreases and cause degenerations of joints. It is proved that glucosamine sulphate takes part in the synthesis of the tissue of normal articulation cartilage, joints fluid and internal enzymes of joint, relieves joint inflammation, improves joint irrigation and eases the movement of the joint. Glucosamine sulphate decreases the activity of enzymes that destroy the structure of the cartilage and protects cartilage from the free radicals.

Chondroitin

Chondroitin is a high molecular mass polysacharid. It is one of the most important components of cartilages and tendons, responsible for the elasticity of joints. Chondroitin keeps the water in the cartilages of joints, stimulates the regeneration of joint cartilages and improves the condition of tendons. With years amount of chondroitin sulfate in the cartilages of joints decrease and joints become less elastic and mobile.

Methylsulfonylmethane

It is a natural substance that participates in many biochemical reactions of the body and is responsible for the synthesis of new and healthy cells. According to clinical researches it:
• suppresses the pain impulse in the nerve ends,
• inflammation,
• decrease the spasms of muscles, joints and ligaments,
• dilates the blood vessels and improves the blood circulation,
• softens the scars,
Literature also describes the positive Methylsulfonylmethane effect in patients with alergic diseases, bronchial asthma, migraine, connective tissue diseases (lupus, sclerodermia), sinusitis.
Methylsulfonylmethane helps to rebuilt the structure of joints damaged by osteoarthritis. It reduces the pain and swelling, stops the fragmentation of damaged tissue, improves the flexibility of joints and the blood circulation of muscles, ligaments and tendons. It may be used for the common therapy to reduce the pain and inflammation. It does not irritate the stomach or cause any undesirable effects.

Scientific researches demonstrating the efficiency

* 55 patients with allergic rhinitis received 2.6 g of Methylsulfonylmethane. The symptoms of allergic rhinitis decreased in 7 days and disappeared in 30 days (Barrager, et al., 2002).
* Randomized, double blind, placebo controlled trials were performed with 50 people with osteoarthritis. There were no undesirable reactions even in administration of 6g of Metilsulfonilmetan for 3 months .(Kim, et al., 2002)
* Double blind, placebo controlled, randomized trials were performed. The effect of glucosamine was compared with the effect of ibuprofen. Ibuprofen had more instant outset of action but after 4 weeks the effect of two drugs was the same. But ibuprofen caused some undesirable reactions (especially in digestion system). (Müller-Fassbender H, Bach GL, Haase W, Rovati LC, Setnikar I. Glucosamine sulfate in osteoarthritis of the knee. Osteoarthritis Cartilage 1994; 2:61-69).
* The randomized, placebo controlled trials that were carried out for three years with 212 patients with knee osteoarthritis were recorded. The effect of glucosamine and placebo was compared. The administration of glucosamine markedly relieved the articular pain, stopped the process and progress of cartilage fragmentation. Placebo group didn't show any of these changes. .( McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteo-arthritis: a systematic quality assessment and meta-analysis. JAMA 2000; 283:1469-1475).

Literature:

1. Vas A L (1982) Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthritis of the knee is outpatients. Current Medical Research and Opinion 8: 145.
2. MSM Racehorse Study. Evidence as to the effectiveness of the use of oral Alavis MSM (Methylsulfonylmethane) By Ronald J. Riegel. 2001 24 01.
3. Theodosakis J,. Adderly B, Fox B (1997) The Arthritis Cure London: Century Books
4. Balch, Phyllis A, CNC, and Balch, James F., M.D., authors, Prescription for Nutritional Healing
5. Baker DH. Utilization of isomers and analogs of amino acids and other sulfur containing compounds. Progr Food Nutr Sci 1986;10:133-178.
6. Childs SJ. Dimethyl sulfone (DMSO2) in the treatment of interstitial cystitis. Urol Clin North Am 1994;21:85-88.
7. Herschler RJ. Methylsulfonylmethane and methods of use. U.S. Patent No.4,296,130; October 21, 1981.
8. Herschler R. Methylsulfonylmethane and composition comprising it. U.S.Patent No. 4,616,039; October 7, 1986.
9. arcell S. (2002) "Sulfur in human nutrition and applications in medicine." Altern Med Rev. 2002 Feb;7(1):22-44. Online
10. Barrager E, Veltmann JR Jr, Schauss AG, Schiller RN. "A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis." J Altern Complement Med. 2002 Apr;8(2):167-73